Lens Lipid Peroxides and Glutathione Concentrations in Diabetic Cataract
نویسندگان
چکیده
منابع مشابه
Lens superoxide dismutase and catalase activities in diabetic cataract.
OBJECTIVE Biochemical evidence suggests that the oxidative damage of the lens proteins is involved in the genesis of senile cataract and the development of diabetes-related pathologic changes such as the formation of cataracts. In particular, lens proteins are subject to extensive oxidative modification. Oxidative damage either decreases the antioxidant capacity or decreased antioxidant capacit...
متن کاملThe Effect of Silybum marianum (L.) Gaertn. Seed Extract (Silymarin) on Galactose Induced Cataract Formation in Rats
Background: Increased oxygen free radical and reduced glutathione level in the eye lens are important risk factor for cataract formation. The antioxidative property and increasing cellular and extra cellular glutathione level have been reported by several herbal medicines including silymarin. Objective: In present interventional study Silybum marianum L. seed extract (silymarin) was tested a...
متن کاملGlutathione peroxidase activity, lipid peroxides and selenium status in blood in patients with Down's syndrome.
The concentrations of selenium and lipid peroxides and the catalytic activity of glutathione peroxidase were measured in the blood of 6 children (6-16 years of age) and 8 adults (17-27 years old) with Down's syndrome (trisomy 21). The values were compared with those for a control group of age-matched normal people. The selenium concentration in whole blood, erythrocytes and plasma was significa...
متن کامل2347 Diabetic cataract and oxidative degradation of lens proteins
Purpose: Lipid peroxidation has recently been associated to a number of agcrelated diseases including cataract development. This study was designed to establish the best conditions to adapt a technical approach based on the incorporation of a fluorescent pmbe (patina& acid) into biological membranes to monitor early stages of lipid pemxidation. The method allows both the evaluation of several f...
متن کاملDiabetic cataract formation: potential role of glycosylation of lens crystallins.
A high glucose concentration in vivo or an increased glucose of glucose 6-phosphate concentration in vitro has been found to lead to the glycosylation of epsilon-amino groups of lysine residues in bovine and rat lens crystallins. In vitro, this glycosylation imparts an increased susceptibility of the crystallins to sulfhydryl oxidation. Disulfide crosslinks result in the formation of high molec...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 1997
ISSN: 0004-5632,1758-1001
DOI: 10.1177/000456329703400211